Bioinspired Antibacterial-Antioxidant Bioactive Hydrogel Synchronizes Immunomodulation-Microenvironment Remodeling for Infected Wound Regeneration

This study developed an innovative antibacterial and antioxidant bioactive hydrogel dressing (BD@HH6) using photo-polymerization of GelMA, Ac-β-CD, HAMA-DA, and HTCCMA, enhanced with PDA and loaded with bFGF. The hydrogel demonstrated rapid gelation (15 seconds), strong tissue adhesion, high antioxidant activity (>95% RNS scavenging), thermal stability, and effective hemostatic capacity (BCI: 16.1%). It also provided controlled release of bFGF, offering a promising solution for infected wound management by combining rapid antimicrobial action with sustained regenerative capacity. This multifunctional system addresses the limitations of conventional wound dressings, providing a new approach for managing complex infected wounds by integrating infection control and tissue regeneration.