Autonomous, Moisture-Driven Flexible Electrogenerative Dressing for Enhanced Wound Healing

This study presents an innovative autonomous, moisture-driven flexible electrogenerative dressing (AMFED) designed to enhance chronic wound healing. The AMFED combines a moist-electric generator (MEG), an antibacterial hydrogel dressing, and molybdenum electrodes to create a self-sustaining electrical supply that combats bacteria like Staphylococcus aureus and Escherichia coli. The MEG generates a stable direct current of 0.61 V from moisture, providing therapeutic electrical stimulation to wounds. The dressing promotes macrophage polarization to the reparative M2 phenotype and regulates inflammatory cytokines. In vivo studies using a diabetic mouse model show that the AMFED accelerates wound healing by approximately 41% compared to controls, supporting nerve regulation, epithelial migration, and vasculogenesis. This research introduces a promising platform for improving chronic wound treatment.