A Stretchable Wireless Wearable Bioelectronic System for Multiplexed Monitoring and Combination Treatment of Infected Chronic Wounds

The study introduces a wearable bioelectronic system designed for chronic nonhealing wounds, which wirelessly monitors wound conditions and provides noninvasive combination therapy. This system uses a multiplexed multimodal electrochemical biosensor array to track physiological conditions and administers controlled anti-inflammatory antimicrobial treatment alongside electrical stimulation for tissue regeneration. The patch is biocompatible, flexible, and adheres to the skin throughout healing. Preclinical in vivo experiments demonstrated the patch's high accuracy and stability in monitoring wound biomarkers, and the combination therapy significantly accelerated wound healing in a rodent model.