A Wearable and Stretchable Dual-Wavelength LED Device for Home Care of Chronic Infected Wounds

The study presents a novel wearable and flexible dual-wavelength LED device designed for home care of chronic infected wounds. This device, which integrates red and blue LEDs, is controlled via a mobile system, ensuring safe and comfortable self-application. It is paired with a sprayable fibrin gel containing thymoquinone and NADH, which work synergistically with the LEDs. The blue light-sensitive thymoquinone effectively eradicates microbes and biofilms, while the red light-synergistic NADH enhances mitochondrial function in macrophages and endothelial cells, promoting wound healing and reducing inflammation. The efficacy of this technology was validated in infected diabetic wounds in mice and minipigs, showing significant promise for at-home phototherapy applications.