Bilayer Dressing Based on Aerogel/Electrospun Mats With Self-Catalytic Hydrogen Sulfide Generation and Enhanced Antioxidant Ability

The study presents a bilayer wound dressing that can self-catalytically generate hydrogen sulfide (H2S), which is known to promote cell proliferation, stimulate angiogenesis, and resist inflammation. The dressing is made of a bio-macromolecular H2S donor based on a keratin–TA conjugate (KTC) loaded into a gelatin hydrogel, and polyurethane electrospun with glutathione (GSH). The dressing can control and sustain the release of H2S, promote cell proliferation and migration, and has enhanced antioxidant ability and reactive oxygen species (ROS) scavenging capability. When tested on a full-thickness excisional cutaneous wound model in rats, the dressing reduced inflammation, promoted vascularization, and facilitated hair follicle regeneration, thereby accelerating wound healing. This suggests potential applications in the field of wound dressing.