Triboelectro-Responsive DNA Hydrogels for Accelerated Healing of Bacterium-Infected Diabetic Wounds
June 2025
in “
Nano Energy
”
Studysummary This study reports that triboelectro-responsive DNA hydrogels, enhanced with conductive polymers and triboelectric stimulation, effectively accelerate wound healing and exhibit strong anti-bacterial and anti-inflammatory properties, achieving 99.8% closure of bacterium-infected diabetic wounds in 14 days.
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The study presents the development of triboelectro-responsive DNA hydrogels integrated with a triboelectric nanogenerator (TENG) to enhance the healing of bacterium-infected diabetic wounds. These hydrogels, which incorporate conductive polymers, improve bioelectrical behavior and facilitate drug delivery in response to acute wound events. The system demonstrates excellent anti-bacterial and anti-inflammatory properties, promoting collagen deposition, angiogenesis, and hair follicle regeneration. Remarkably, the hydrogels achieve a 99.8% closure of infected wounds within 14 days, suggesting their potential as next-generation smart dressings for chronic diabetic wound therapy.
