Bioengineered Microneedles and Nanomedicine as Therapeutic Platform for Tissue Regeneration

August 2025 in “ Journal of Nanobiotechnology ”

Y T Mao, Shihui Xu, Xiaozhou Shi, Yanjia Jin, Zihan Pan, Hao Tian, Guoping Li, Xuerui Chen, Hongdong Wang, Yongtao Wang, Junjie Xiao

bioengineered microneedles nanomedicine tissue regeneration chronic wounds degenerative diseases polymers metals drug delivery dissolving microneedles hollow microneedles controlled drug delivery targeted drug release responsive drug release skin regeneration biomaterials biofabrication

Studysummary This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Bioengineered microneedles (MNs) combined with nanomedicine offer a promising platform for tissue regeneration, addressing challenges in chronic wounds, organ damage, and degenerative diseases. MNs, made from materials like polymers and metals, can deliver drugs directly to target sites with precision and minimal invasiveness. Innovations such as dissolving and hollow structures enhance controlled drug delivery, while nanomedicine integration allows for targeted and responsive drug release. Applications include skin regeneration, cardiovascular repair, and neural regeneration, with potential to revolutionize regenerative medicine through personalized treatments. Despite challenges in scalability and biocompatibility, advancements in biomaterials and biofabrication suggest a promising future for MNs in precision regenerative medicine.

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