Advances in Clinical Applications of Microneedle

June 2025 in “ Frontiers in Pharmacology ”

Kequan Chen, Xinyu Sun, Y. Liu, Shiyu Li, Dianhuai Meng

microneedle transdermal drug delivery biosignal detection biomarker monitoring gene therapy immunostimulation wound healing scar repair anti-aging skin disease treatment

TLDR Microneedles improve drug delivery, patient compliance, and have potential in cancer treatment and skin care.

Microneedle (MN) technology has advanced significantly in clinical applications, offering minimally invasive methods for drug delivery, biosensing, cancer therapy, and skin disease treatment. MNs improve drug delivery efficiency, patient compliance, and reduce side effects. They are used in cancer treatment, vaccines, contraception, anesthesia, and specialized drug administration. Recent developments include MNs for ocular treatments, diabetes management, tumor diagnosis, and wound healing. In androgenetic alopecia (AGA), MNs promote hair growth through methods like PRP-MNs and AR-PROTAC-MNs, offering sustainable results without systemic toxicity. Despite these advancements, challenges in delivery depth, immune effects, and material selection remain, with future research focusing on overcoming these issues and expanding MN applications.

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Advances in Clinical Applications of Microneedle

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