3D Bioprinting of Engineered Exosomes Secreted from M2-Polarized Macrophages Through Immunomodulatory Biomaterial Promotes In Vivo Wound Healing and Angiogenesis
November 2024
in “
Bioactive Materials
”
3D bioprinting engineered exosomes M2-polarized macrophages immunomodulatory biomaterial wound healing angiogenesis bifunctional hydrogel inks M2 macrophage polarization polyamine-modified hydrogels collagen decellularized extracellular matrix JAK/STAT signaling pathway PPAR signaling pathway M2-Exo secretion skin cells MAPK signaling pathway wound remodeling hair follicle induction pro-inflammatory activation 3D printing exosomes macrophages biomaterial hydrogels extracellular matrix JAK/STAT pathway PPAR pathway skin MAPK pathway hair growth
TLDR 3D bioprinting with special hydrogels helps heal wounds and grow new blood vessels.
The study demonstrates the potential of 3D bioprinted hydrogels containing engineered exosomes from M2-polarized macrophages to enhance wound healing and angiogenesis. The hydrogels, which incorporate exosomes, showed high biocompatibility and promoted cell proliferation, migration, and angiogenesis in skin and endothelial cells. In vivo tests on a rat model revealed that these hydrogels significantly accelerated wound healing, reduced scar formation, and decreased inflammation. The research highlights the hydrogel's ability to modulate immune responses and suggests its potential for personalized skin grafts and traumatic wound healing, offering a promising strategy in skin tissue engineering and regenerative medicine.
