A 3R (Remove-Remodel-Repair)-Integrated Self-Assembled Chlorella-Gelatin-PEG Hydrogel for Diabetic Wound Healing
June 2025
in “
Materials Today Bio
”
Studysummary In diabetic mice, this study reported that the multifunctional hydrogel CPGel achieved complete wound closure in 21 days, showing promise in improving chronic wound healing through antibacterial, antioxidative, and tissue regeneration properties.
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The study introduces CPGel, a novel hydrogel for diabetic wound healing, combining Chlorella extracts, gelatin, and PEG. It employs a 3R strategy: Remove (antibacterial activity), Remodel (ROS scavenging and macrophage polarization), and Repair (enhanced angiogenesis and collagen deposition). In diabetic mice, CPGel achieved 100% wound closure in 21 days, outperforming controls. The hydrogel's mechanical robustness, transparency, and adhesion make it a promising, scalable, and toxin-free solution for chronic wound management, effectively integrating traditional herbal medicine with advanced biomaterial engineering.
