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This study found that 3D-printed polyamine-modified hydrogels facilitate M2 macrophage polarization and exosome secretion, enhancing skin cell compatibility and promoting wound healing and hair follicle induction in an animal model through specific signaling pathways, suggesting potential for skin disorder therapies.

This study found that macrophages treated with keratin in vitro were more similar to anti-inflammatory M2 macrophages and reduced astrocyte reactivity, potentially limiting secondary inflammatory damage after spinal cord injury.

This study demonstrated that CEP may effectively treat pulmonary fibrosis by inhibiting fibroblast activation through regulating macrophage M2 polarization and decreasing fibrosis-associated factors, suggesting a new avenue for future research in this area.

This study found that mechanical skin stretching can stimulate hair stem cell proliferation and hair regeneration by activating a complex pathway involving WNT, BMP-2, and M2 macrophages.

This study suggests that M2 macrophages play a key role in promoting wound-induced hair neogenesis in mice by producing growth factors like Igf1 and Fgf2.