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This study found that 3D-printed polyamine-modified hydrogels facilitate M2 macrophage polarization and exosome secretion, enhancing skin cell compatibility and promoting wound healing and hair follicle induction in an animal model through specific signaling pathways, suggesting potential for skin disorder therapies.

In an animal model, this study found that PEG hydrogels delivering M2 macrophage-derived exosomes effectively promoted M1 to M2 macrophage transition and enhanced wound healing.

This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.

This literature review reports that mesenchymal stem cell-derived secretome, including conditioned medium and extracellular vesicles, shows promise as an effective treatment for various diseases in animal and human in-vivo models, with ongoing clinical trials and recommendations for future research discussed.

This review suggests that the umbilical cord-derived mesenchymal stem cell secretome presents a promising approach for skin regeneration and wound healing due to its multiple therapeutic properties, highlighting its potential over traditional treatments for conditions like chronic wounds and alopecia.