Granulocyte Colony Stimulating Factor Promotes Scarless Tissue Regeneration

    September 2024 in “ Cell Reports ”
    Jianhe Huang, Satish Sati, Christina Murphy … Thomas Leung
    Studysummary This study found that mice lacking the CXCR2 receptor regenerated tissue scarlessly in various injury models and that administering plasma or G-CSF from these mice to wild-type mice also reduced scarring, suggesting potential therapeutic strategies to improve human skin wound healing.
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    Research cited in this study 4

    1. Immune-Epithelial Cross Talk in Regeneration and Repair Annual Review of Immunology · 2023
    2. Neutrophil Extracellular Traps Impair Regeneration Journal of Cellular and Molecular Medicine · 2021
    3. M2 Macrophages Promote Wound-Induced Hair Neogenesis Journal of Dermatological Science · 2018
    4. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007