ALKBH5-Mediated m6A Demethylation Fuels Cutaneous Wound Re-Epithelialization by Enhancing PELI2 mRNA Stability

    July 2023 in “ Inflammation and Regeneration ”
    Xin Huang, Yixuan Zhao, Daiming Liu … Tao Zan
    Studysummary This study found that ALKBH5 plays a critical role in wound re-epithelialization by enhancing the stability of PELI2 mRNA, and its absence delays wound healing. Supplementation with PELI2 can partially rescue this delay, pointing to potential new therapies for stubborn wounds.
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    Research cited in this study 1

    1. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021