Poly-D,L-Lactic Acid Filler Increases Hair Growth by Modulating Hair Follicular Stem Cells in Aged Skin

December 2025 in “ Cells ”

Seyeon Oh, Jino Kim, Hye-Young Choi, Hyung Sun Yoo, Kuk Hui Son, Kyunghee Byun

Poly-D,L-lactic acid PDLLA hair follicular stem cells HFSCs Piezo1 M2 macrophage polarization growth factors HGF IGF-1 RAS/ERK signaling pathway Wnt/β-catenin signaling pathway anagen phase hair follicle regeneration

TLDR Poly-D,L-lactic acid boosts hair growth in aged skin by activating hair follicle stem cells.

The study explores the effects of Poly-D,L-lactic acid (PDLLA) on hair growth in aged skin by modulating hair follicular stem cells (HFSCs). PDLLA enhances hair growth by activating Piezo1, which promotes M2 macrophage polarization and increases the secretion of growth factors like HGF and IGF-1. These factors activate the RAS/ERK and Wnt/β-catenin signaling pathways, leading to increased HFSC proliferation and anagen phase induction. Experiments on middle-aged mice showed that PDLLA significantly increased hair follicle number, diameter, and length, suggesting its potential as a treatment for age-related hair loss. The study involved 5 mice per group, highlighting PDLLA's promise in enhancing HFSC activity and hair follicle regeneration.

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