Restoration of Hair Follicle Inductive Properties by Depletion of Senescent Cells

The study examines the impact of senescent dermal papilla (DP) cells on hair follicle inductive properties and the potential of senolytic drugs to restore these properties. Senescent DP cells secrete SASP factors that negatively affect non-senescent DP cells, reducing hair inductivity. The research found that the senolytic combination of dasatinib and quercetin effectively depleted senescent cells, reversing their repressive effects and enhancing hair growth-related gene expression. This approach improved hair follicle regeneration in both in vitro and in vivo experiments, particularly at early culture passages, offering a promising strategy for treating permanent hair loss by targeting senescent cells.