(/r/science X-post): Stress may turn your hair grey. The appearance of grey hairs after periods of stress or skin damage could be the result of depletion of stem cells from the base of the hair follicle, according to a new study : science 6/10/2013
Stress can cause hair to turn grey due to stem cell depletion at the hair follicle base. Treatments discussed include Minoxidil, finasteride, and RU58841 for hair loss.
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5 / 5 resultscommunity Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results
ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.
community Reminder: NURTURE those dormant hair follicles for as long as you can until PP405 comes out in 2028-2030
PP405 is anticipated as a future treatment for dormant hair follicles, but its effectiveness and safety are uncertain. Current treatments include oral minoxidil and microneedling, with some avoiding finasteride due to side effects.
community Dutasteride is not maintaining my hair. What are some other good options?
The user is experiencing diffuse hair loss despite using finasteride and dutasteride and is considering adding minoxidil, microneedling, or RU58841. They are also thinking about increasing the dutasteride dose or opting for a hair transplant, while being cautious about side effects.
community Hair loss research is a money grab
Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.
community PP405 could be released before GTA 6
PP405 is discussed as a potential hair loss treatment, but its effectiveness and safety are uncertain. Some users express skepticism, while others are hopeful, comparing it to existing treatments like Minoxidil and Finasteride.
Related Research
6 / 6 resultsresearch Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp
This study found that ATM protein plays a crucial role in protecting human hair follicle melanocytes from oxidative stress, which is linked to the greying of hair.
research Single-cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying
This study used single-cell RNA sequencing to create a detailed atlas of human scalp hair follicles and found that early-stage hair graying involves matrix hair progenitor depletion linked to P53 pathway activation.
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This study found that PBMCsec has anti-fibrotic effects on mouse and human skin scars by regulating pro-fibrotic gene expression and inhibiting myofibroblast differentiation and elastic fiber breakdown.
research Porcine acellular dermal matrix facilitates hair follicle stem cells entering the hair cycle in C57/BL6 mice
In this study, porcine collagen acellular dermal matrix scaffolds combined with mice platelet-rich plasma were associated with increased hair density and follicle regeneration in mice with alopecia, suggesting a potential therapeutic approach.
research Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment
In a mouse model of androgenetic alopecia, this study found that a novel hydrogel containing minoxidil-incorporated engineered exosomes (Gel@MNs) enhanced hair regeneration more effectively than conventional minoxidil, increasing hair follicle number and size while reducing skin irritation.
research Safety and efficacy of ALRV5XR in men with androgenetic alopecia: A randomised, double-blinded, placebo-controlled clinical trial
In this study, ALRV5XR treatment significantly increased terminal hair density in men with androgenetic alopecia after 24 weeks, while also decreasing vellus hair density, and was well tolerated without adverse events, suggesting its potential efficacy over standard therapies.