Porcine Acellular Dermal Matrix Facilitates Hair Follicle Stem Cells Entering the Hair Cycle in C57/BL6 Mice

The study explores the potential of porcine acellular dermal matrix (ADM) to promote hair regeneration in C57BL/6 mice by facilitating hair follicle stem cells entering the hair cycle. ADM scaffolds, especially when combined with platelet-rich plasma (PRP), significantly enhanced the transition of hair follicles from the telogen to the anagen phase, resulting in increased hair regrowth and higher hair follicle numbers. The ADM scaffold activated key signaling pathways, such as Wnt/β-catenin, and increased the expression of proteins crucial for hair follicle development, like Sox9 and Lef-1. The study suggests that ADM scaffolds could be a promising alternative to traditional hair loss treatments, offering a therapeutic approach that stimulates native stem cells without systemic side effects.