Effect of Porcine Acellular Dermal Matrix on the Expression of Stromal Cell-Derived Factor-1 and Wnt3a/β-Catenin Signaling Pathway in Mice Hair Follicle Regeneration

February 2019 in “ Chin J Injury Repair and Wound Healing(Electronic Edition) ”

Ye Du, Zibo Feng, Gongchi Li, Lijun Zou, Hong Yang, Zhi Wang, Jianghai Chen, Yingen Pan, Binghui Li

porcine acellular dermal matrix ADM hair follicle regeneration C57BL/6 mice full-thickness skin defects β-catenin Wnt3a SDF-1 Western blotting immunohistochemistry scaffold for hair growth hair loss conditions acellular dermal matrix hair growth scaffold

TLDR Porcine acellular dermal matrix helps hair growth by boosting specific proteins and signals.

The study investigated the effects of porcine acellular dermal matrix (ADM) on hair follicle regeneration in 18 C57BL/6 mice with full-thickness skin defects. Results showed that ADM significantly increased the expression of β-catenin, Wnt3a, and SDF-1 compared to gauze, as confirmed by Western blotting and immunohistochemistry. The study concluded that ADM promoted hair follicle regeneration by up-regulating SDF-1 and the Wnt3a/β-catenin signaling pathway, suggesting its potential as a scaffold for hair growth and treating hair loss conditions.

View this study on zhssyxfzz.cma-cmc.com.cn →

Discuss this study in the Community →

Related Research

2 / 2 results

research Inhibitory Effect of Angiogenin on the Expression of Type I Collagen and Fibronectin in Dermal Papilla Cells from Androgenetic Alopecia Areas

September 2018 in “Chinese Journal of Dermatology”

Angiogenin may help treat hair loss by reducing certain proteins in hair cells.

In Vitro Effects of the Phytocomplex TrichoTech on Human Fibroblasts: Proliferative Potential and Effects on Gene Expression of FGF-7 and FGF-10

research In Vitro Effects of the Phytocomplex TrichoTech on Human Fibroblasts: Proliferative Potential and Effects on Gene Expression of FGF-7 and FGF-10

2 citations, January 2017 in “Journal of Cosmetics, Dermatological Sciences and Applications”

TrichoTech™ may help hair growth and skin repair by increasing fibroblast growth and activity.

Effect of Porcine Acellular Dermal Matrix on the Expression of Stromal Cell-Derived Factor-1 and Wnt3a/β-Catenin Signaling Pathway in Mice Hair Follicle Regeneration

Related Community Posts Join

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

community Obviously, all of us who are serious take antiandrogens and growth stimulants - what else are you doing lifestyle wise, dietary wise, and regiment wise to maximize your results?

Related Research

research Inhibitory Effect of Angiogenin on the Expression of Type I Collagen and Fibronectin in Dermal Papilla Cells from Androgenetic Alopecia Areas

research In Vitro Effects of the Phytocomplex TrichoTech on Human Fibroblasts: Proliferative Potential and Effects on Gene Expression of FGF-7 and FGF-10