Inhibitory Effect of Angiogenin on the Expression of Type I Collagen and Fibronectin in Dermal Papilla Cells from Androgenetic Alopecia Areas

    September 2018 in “ Chinese Journal of Dermatology ”
    Naihui Zhou, Yan Li, Yueqian Zhu, Sun Ren, Miaomiao Wang
    TLDR Angiogenin may help treat hair loss by reducing certain proteins in hair cells.
    The study investigated the effect of angiogenin on the expression of type I collagen and fibronectin in dermal papilla cells from androgenetic alopecia areas. It was found that angiogenin significantly inhibited the expression of these extracellular matrix components in vitro. The mechanism was likely related to the downregulation of TGF-β1 expression and inhibition of the TGF-β1/Smad signaling pathway. The study demonstrated that angiogenin could counteract the effects of dihydrotestosterone, which increased the expression of type I collagen, fibronectin, and TGF-β1 mRNA in dermal papilla cells. The findings suggested a potential therapeutic role for angiogenin in treating androgenetic alopecia by modulating extracellular matrix expression.
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