Induction of Hair Follicle Regeneration in Mice Ear by Microencapsulated Human Hair Dermal Papilla Cells

    March 2006 in “ Chinese journal of plastic surgery ”
    Yu You Li, Lin Changmin, Xiang-na Cai, Guoqiang Li, Keng Yen Huang
    TLDR Microencapsulated human hair cells can regenerate hair follicles in mice ears.
    The study aimed to induce hair follicle regeneration in mice ears using microencapsulated human hair dermal papilla cells (DPs). DPs were encapsulated with alginate-polylysine-alginate and xenotransplanted into mice ears. After 6 weeks, histological examination showed fully developed hair follicles at the implantation sites, differing significantly from control groups. Fluorescein diffusion studies indicated that smaller microencapsulations had higher fluorescein intensity. The study concluded that microencapsulated DPs retained their ability to induce follicle regeneration, with 400 µm diameter microencapsulations being optimal for nutrient and metabolite exchange while isolating immunocompetent substances.
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