Induction of Hair Follicle Regeneration in Mice Ear by Microencapsulated Human Hair Dermal Papilla Cells
March 2006
in “
Chinese journal of plastic surgery
”
hair follicle regeneration microencapsulated human hair dermal papilla cells dermal papilla cells alginate-polylysine-alginate xenotransplantation histological examination fluorescein diffusion microencapsulations nutrient exchange metabolite exchange immunocompetent substances DPs microencapsulation
TLDR Microencapsulated human hair cells can regenerate hair follicles in mice ears.
The study aimed to induce hair follicle regeneration in mice ears using microencapsulated human hair dermal papilla cells (DPs). DPs were encapsulated with alginate-polylysine-alginate and xenotransplanted into mice ears. After 6 weeks, histological examination showed fully developed hair follicles at the implantation sites, differing significantly from control groups. Fluorescein diffusion studies indicated that smaller microencapsulations had higher fluorescein intensity. The study concluded that microencapsulated DPs retained their ability to induce follicle regeneration, with 400 µm diameter microencapsulations being optimal for nutrient and metabolite exchange while isolating immunocompetent substances.
