Induction of Hair Follicle Regeneration in Mice Ear by Microencapsulated Human Hair Dermal Papilla Cells

    March 2006 in “ Chinese journal of plastic surgery ”
    Yu You Li, Lin Changmin, Xiang-na Cai, Guoqiang Li, Keng Yen Huang
    TLDR Microencapsulated human hair cells can regenerate hair follicles in mice ears.
    The study aimed to induce hair follicle regeneration in mice ears using microencapsulated human hair dermal papilla cells (DPs). DPs were encapsulated with alginate-polylysine-alginate and xenotransplanted into mice ears. After 6 weeks, histological examination showed fully developed hair follicles at the implantation sites, differing significantly from control groups. Fluorescein diffusion studies indicated that smaller microencapsulations had higher fluorescein intensity. The study concluded that microencapsulated DPs retained their ability to induce follicle regeneration, with 400 µm diameter microencapsulations being optimal for nutrient and metabolite exchange while isolating immunocompetent substances.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community How Does Exosome Therapy Work for Hair Loss?

      in Research/Science  5 upvotes 1 year ago
      Exosome hair therapy involves injecting stem cell-derived exosomes into the scalp to boost hair follicle regeneration and repair. Exosomes, which are not stem cells but products of them, contain bioactive chemicals and specific growth factors that promote new blood vessel formation, increase cell proliferation, reduce inflammation, and improve tissue repair, all crucial for hair health.

      community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

      in Research/Science  13 upvotes 6 months ago
      A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Related Research

    9 / 9 results