Melatonin for Hair Regrowth: Preclinical Insights, Current Evidence, and Future Perspectives

    Weeratian Tawanwongsri, Chime Eden
    Studysummary This review suggests that melatonin may increase hair density and reduce hair shedding, but variations in study designs highlight the need for more standardized clinical trials.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ejgm.co.uk →
    Discuss this study in the Community →

    Research cited in this study 32

    1. Integrative Transcriptomic and Metabolomic Analyses Reveal the Role of Melatonin in Promoting Secondary Hair Follicle Development in Cashmere Goats BMC Genomics · 2025
    2. The Retinoic Acid-Related Orphan Receptor Alpha May Be Highly Involved in the Regulation of Seasonal Hair Molting International Journal of Molecular Sciences · 2025
    3. Melatonin-Mediated Circadian Rhythm Signaling Exhibits Bidirectional Regulatory Effects on the State of Hair Follicle Stem Cells Biomolecules · 2025
    4. Melatonin Promotes the Proliferation of Dermal Papilla Cells in Cashmere Goats via Activation of Chi-let-7d-5p/WNT2 Axis Genomics · 2024
    5. Melatonin Promotes Hair Regeneration by Modulating the Wnt/β-Catenin Signaling Pathway Cell proliferation · 2024
    6. Melatonin Promotes Proliferation of Inner Mongolia Cashmere Goat Hair Follicle Papilla Cells Through Wnt10b Genomics · 2024
    7. Clinical Efficacy and Safety of Low-Dose Oral Minoxidil Versus Topical Solution in the Improvement of Androgenetic Alopecia: A Randomized Controlled Trial Journal of Cosmetic Dermatology · 2023
    8. Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes Against Paclitaxel-Induced Damage Ex Vivo Journal of Investigative Dermatology · 2023
    9. Melatonin Regulates the Periodic Growth of Secondary Hair Follicles Through the Nuclear Receptor RORα Frontiers in Veterinary Science · 2023
    10. Boosting Hair Growth Through Follicular Delivery of Melatonin Through Lecithin-Enhanced Pickering Emulsion Stabilized by Chitosan-Dextran Nanoparticles in Testosterone Induced Androgenic Alopecia Rat Model International Journal of Pharmaceutics · 2023
    11. Melatonin Promotes the Development of Secondary Hair Follicles by Regulating circMPP5 Journal of Animal Science and Biotechnology · 2023
    12. Mechanism of Action and Promising Clinical Application of Melatonin from a Dermatological Perspective Journal of Translational Autoimmunity · 2023
    13. Identification of Key Pathways and Genes That Regulate Cashmere Development in Cashmere Goats Mediated by Exogenous Melatonin Frontiers in veterinary science · 2022
    14. Melatonin Increases Growth Properties in Human Dermal Papilla Spheroids by Activating AKT/GSK3β/β-Catenin Signaling Pathway PeerJ · 2022
    15. Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus BMC Genomics · 2022
    16. Revisiting the Role of Melatonin in Human Melanocyte Physiology: A Skin Context Perspective Journal of pineal research · 2022
    17. A Randomized Clinical Trial on Therapeutic Effects of 0.25 mg Oral Minoxidil Tablets on Treatment of Female Pattern Hair Loss Dermatologic Therapy · 2021
    18. Role of Sulfur Metabolism Gene and High-Sulfur Gene Expression in Wool Growth Regulation in the Cashmere Goat Frontiers in Genetics · 2021
    19. Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway Frontiers in Cell and Developmental Biology · 2021
    20. Effects of Melatonin Administration to Cashmere Goats on Cashmere Production and Hair Follicle Characteristics in Two Consecutive Cashmere Growth Cycles Domestic Animal Endocrinology · 2020
    21. Expression of Lipid-Protein Gene PLP2 in Liaoning Cashmere Goat Animal biotechnology · 2019
    22. Long Noncoding RNA and Gene Expression Analysis of Melatonin-Exposed Liaoning Cashmere Goat Fibroblasts Indicating Cashmere Growth Naturwissenschaften · 2018
    23. Clinical Cosmeceutical Repurposing of Melatonin in Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared with Antioxidant Oils Expert Opinion on Drug Delivery · 2018
    24. Melatonin Vitamin C-Based Nanovesicles for Treatment of Androgenic Alopecia: Design, Characterization and Clinical Appraisal European Journal of Pharmaceutical Sciences · 2018
    25. Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs Cell Cycle · 2018
    26. Gene Expression and Localization of LAMTOR3 in the Skin Cells of Liaoning Cashmere Goats Animal biotechnology · 2018
    27. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    28. Topical Melatonin for Treatment of Androgenetic Alopecia International Journal of Trichology · 2012
    29. Melatonin and the Hair Follicle Journal of pineal research · 2007
    30. Expression and Functional Relevance of Melatonin Receptors in Hair Follicle Biology Experimental dermatology · 2005
    31. On the Role of Melatonin in Skin Physiology and Pathology Endocrine journal · 2005
    32. Melatonin Increases Anagen Hair Rate in Women With Androgenetic Alopecia or Diffuse Alopecia: Results of a Pilot Randomized Controlled Trial British Journal of Dermatology · 2004