The Retinoic Acid-Related Orphan Receptor Alpha May Be Highly Involved in the Regulation of Seasonal Hair Molting

    February 2025 in “ International Journal of Molecular Sciences ”
    Yu Zhang, Xuefei Zhao, Shuqi Li, Suying Bai, Wei Zhang
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    TLDR RORA plays a key role in controlling seasonal hair molting by affecting hair follicle cell activity.
    This study explores the role of the Retinoic-Acid-Related Orphan Receptor Alpha (RORA) in regulating seasonal hair molting, using the Eurasian red squirrel as a model. RORA, a nuclear receptor for melatonin, is downregulated during winter molting, indicating its involvement in this process. The research shows that RORA inhibits hair follicle stem cell (HFSC) proliferation and promotes apoptosis, while melatonin enhances HFSC viability by downregulating RORA. Activation of RORA affects cell cycle progression, gene expression related to apoptosis and ferroptosis, and oxidative stress markers. These findings suggest that RORA is crucial in hair molting by modulating cellular processes, providing insights into hair follicle development and seasonal changes.
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