Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3

    December 2024 in “ Animals ”
    Yu Zhang, Xuefei Zhao, Shuqi Li … Wei Zhang
    Studysummary In this study, researchers found that RORA directly regulates the expression of the Bnip3 gene, which is crucial for hair follicle stem cell health, using rat HFSCs as a model. They propose that targeting RORA could modulate HFSC status.
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    Research cited in this study 16

    1. Recent Progress in Hair Follicle Stem Cell Markers and Their Regulatory Roles World Journal of Stem Cells · 2024
    2. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    3. Melatonin Regulates the Periodic Growth of Secondary Hair Follicles Through the Nuclear Receptor RORα Frontiers in Veterinary Science · 2023
    4. Hair Follicle Morphogenesis During Embryogenesis, Neogenesis, and Organogenesis Frontiers in Cell and Developmental Biology · 2022
    5. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    6. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    7. Aging in Hair Follicle Stem Cells and Niche Microenvironment The Journal of Dermatology · 2017
    8. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    9. Immunohistochemical Study of Hair Follicle Stem Cells in Regenerated Hair Follicles Induced by Wnt10b International Journal of Medical Sciences · 2016
    10. Expression of the RORα Gene in Inner Mongolian Cashmere Goat Hair Follicles Genetics and molecular research · 2015
    11. The Amazing Mini Organ: Hair Follicle TURKDERM · 2014
    12. Growth and Viability of Liaoning Cashmere Goat Hair Follicles During the Annual Hair Follicle Cycle Genetics and Molecular Research · 2014
    13. Targeted Inactivation of Integrin-Linked Kinase in Hair Follicle Stem Cells Reveals an Important Modulatory Role in Skin Repair After Injury Molecular Biology of the Cell · 2011
    14. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    15. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    16. The Role of Prolactin in the Reactivation of Hair Follicles in Relation to Moulting in Cashmere Goats Journal of Endocrinology/Journal of endocrinology · 1994