Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3

    December 2024 in “ Animals ”
    Yu Zhang, Xuefei Zhao, Shuqi Li, Yanchun Xu, Suying Bai, Wei Zhang
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    TLDR RORA may help regulate hair growth by affecting hair follicle stem cells.
    This study examines the role of Retinoic Acid-Related Orphan Receptor Alpha (RORA) in regulating hair follicle stem cells (HFSCs) by upregulating the expression of the Bnip3 gene, which is involved in apoptosis and autophagy. Using rat HFSCs, researchers found that RORA directly binds to the Bnip3 promoter, enhancing its expression by approximately 1.5-fold. This suggests that RORA may influence HFSC states, providing insights into hair follicle development and maintenance. The study highlights RORA as a potential target for understanding and regulating hair growth and regeneration.
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