Retinoic Acid-Related Orphan Receptor Alpha Is Involved in the Regulation of the Cytoskeleton of Hair Follicle Stem Cells

    June 2025 in “ Biomolecules ”
    Yu Zhang, Xuefei Zhao, Shuqi Li, Suying Bai, Wei Zhang
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    TLDR RORA affects hair follicle stem cells' structure and movement, potentially helping treat hair loss.
    This study explores the role of Retinoic-Acid-Related Orphan Receptor Alpha (RORA) in regulating the cytoskeleton of hair follicle stem cells (HFSCs). Activation of RORA was found to significantly inhibit the transcription and protein expression of genes related to cytoskeletal composition and cell adhesion, such as myosin, tropomyosin, integrins, and cadherins, which in turn affects the migratory and adhesive abilities of HFSCs. The study involved at least three biological replicates and demonstrated statistically significant results, suggesting that RORA's effects on cytoskeleton-related genes may offer new targets for treating hair loss conditions like alopecia. However, the study's reliance on in vitro models indicates a need for further in vivo research.
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