2′-Fucosyllactose Alleviates Hair Loss in Testosterone-Induced Androgenic Alopecia Mice

    January 2025 in “ Journal of Food Biochemistry ”
    So‐Hyun Park, Eunyoung Lee, Daedong Kim, Jongwon Yoon, Seon-Min Jeon, Young‐Ha Song, J Bang, Chang Hwa Jung
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    TLDR 2′‐Fucosyllactose reduces hair loss and promotes hair growth in mice.
    The study explored the effects of 2′‐Fucosyllactose (2′‐FL), a component of human milk oligosaccharides, on androgenic alopecia (AGA) in a testosterone-induced mouse model. The administration of 2′‐FL significantly reduced hair loss and increased hair length and thickness. It achieved this by enlarging hair follicle size, enhancing growth factor expression, and activating β‐catenin signaling through AKT and ERK pathways. Additionally, 2′‐FL suppressed apoptosis signaling and inflammatory cytokines in the skin of AGA mice, highlighting its potential as a therapeutic agent for AGA.
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