2′-Fucosyllactose Alleviates Hair Loss in Testosterone-Induced Androgenic Alopecia Mice

    January 2025 in “ Journal of Food Biochemistry ”
    So‐Hyun Park, Eunyoung Lee, Daedong Kim, Jongwon Yoon, Seon-Min Jeon, Young‐Ha Song, J Bang, Chang Hwa Jung
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    TLDR 2′‐Fucosyllactose reduces hair loss and promotes hair growth in mice.
    The study on 2′-Fucosyllactose (2′-FL) in testosterone-induced androgenic alopecia in B6CBAF1/j mice found that 2′-FL significantly reduced hair loss and cuticle damage, increased hair thickness, and improved hair follicle development by enhancing growth factors and signaling pathways. It also demonstrated anti-inflammatory effects by lowering IL-6 and TNF-α levels. The high-dose 2′-FL group showed similar improvements to the finasteride group, suggesting 2′-FL as a potential natural treatment for androgenic alopecia with minimal side effects. The study involved sample sizes of n > 35 for hair length and n = 5 for hair loss area measurements, but lacked an untreated control group and did not assess gut microbiota.
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