Akkermansia Muciniphila Promotes Testosterone-Mediated Hair Growth Inhibition in Mice

October 2023 in “ FASEB bioAdvances ”

E. H. Lee, Dae‐Dong Kim, Hyo‐Deok Seo, Jeong‐Hoon Hahm, Jae‐Gu Seo, Sang‐Nam Lee, Dohak Kim, Jiyun Ahn, Chang Hwa Jung

Akkermansia muciniphila testosterone hair growth inhibition C57BL/6 mice finasteride hair follicle density β-catenin cyclin D1 hormonal hair loss signaling pathways Akk Propecia

Studysummary This study investigated the effects of Akkermansia muciniphila on testosterone-induced hair growth inhibition in mice, finding that both live and pasteurized forms significantly encouraged hair growth and increased hair follicle size and growth factor levels compared to testosterone treatment alone. Our plain-language summary of this paper — not a Tressless recommendation.

The study examined the impact of Akkermansia muciniphila (Akk) on testosterone-induced hair growth inhibition in C57BL/6 male mice over 5 weeks. Mice treated with live and pasteurized Akk showed significant hair growth and increased hair follicle density, similar to the finasteride-treated group. Akk enhanced the expression of hair growth-related factors like β-catenin and cyclin D1. The study suggests that Akk could potentially counteract hormonal hair loss by regulating key signaling pathways, although further clinical studies are necessary to confirm its effectiveness.

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