Akkermansia Muciniphila Promotes Testosterone-Mediated Hair Growth Inhibition in Mice

October 2023 in “ FASEB bioAdvances ”

E. H. Lee, Dae‐Dong Kim, Hyo‐Deok Seo, Jeong‐Hoon Hahm, Jae‐Gu Seo, Sang‐Nam Lee, Dohak Kim, Jiyun Ahn, Chang Hwa Jung

Akkermansia muciniphila testosterone hair growth inhibition C57BL/6 mice finasteride hair follicle density β-catenin cyclin D1 hormonal hair loss signaling pathways Akk Propecia

TLDR Akkermansia muciniphila may help prevent testosterone-related hair loss.

The study examined the impact of Akkermansia muciniphila (Akk) on testosterone-induced hair growth inhibition in C57BL/6 male mice over 5 weeks. Mice treated with live and pasteurized Akk showed significant hair growth and increased hair follicle density, similar to the finasteride-treated group. Akk enhanced the expression of hair growth-related factors like β-catenin and cyclin D1. The study suggests that Akk could potentially counteract hormonal hair loss by regulating key signaling pathways, although further clinical studies are necessary to confirm its effectiveness.

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Akkermansia Muciniphila Promotes Testosterone-Mediated Hair Growth Inhibition in Mice

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