Gynostemma Pentaphyllum Hydrodistillate and Its Major Component Damulin B Promote Hair Growth via the Wnt/Beta-Catenin Pathway

    March 2024 in “ Nutrients ”
    Lochana Kovale, Seo Yeon Lee, Minhyeok Song … Joohun Ha
    Studysummary This study found that Gynostemma pentaphyllum leaf hydrodistillate (GPHD) promoted hair growth in mice similarly to minoxidil and upregulated growth factor expression via the AKT/β-catenin signaling pathway, with damulin B identified as an active component contributing to these effects.
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    Research cited in this study 40

    1. Effect of cyclosporine A - tempol topical gel for the treatment of alopecia and anti-inflammatory disorders International Journal of Pharmaceutics · 2023
    2. Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism of Action Current Issues in Molecular Biology · 2023
    3. Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells Marine Drugs · 2023
    4. Baricitinib for the Treatment of Alopecia Areata Drugs · 2023
    5. Comorbidities in Androgenetic Alopecia: A Comprehensive Review Dermatology and therapy · 2022
    6. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    7. Effects of the PI3K/Akt Signaling Pathway on the Hair Inductivity of Human Dermal Papilla Cells in Hair Beads Journal of Bioscience and Bioengineering · 2022
    8. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    9. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    10. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    11. Cyclosporine With and Without Systemic Corticosteroids in Treatment of Alopecia Areata: A Systematic Review Dermatology and therapy · 2020
    12. PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration Stem Cell Research & Therapy · 2020
    13. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    14. Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/β-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2019
    15. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    16. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    17. Olfactory Receptor OR2AT4 Regulates Human Hair Growth Nature Communications · 2018
    18. Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells Stem cells · 2017
    19. The Impact of Oxidative Stress on Hair International Journal of Cosmetic Science · 2015
    20. Red Ginseng Extract Promotes Hair Growth in Cultured Human Hair Follicles Journal of Medicinal Food · 2014
    21. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    22. An Overview of Alopecias Cold Spring Harbor Perspectives in Medicine · 2014
    23. Cause of Androgenic Alopecia Plastic and reconstructive surgery. Global open · 2013
    24. Low-Level Laser Therapy for Treatment of Hair Loss Lasers in Surgery and Medicine · 2013
    25. The Contribution of Endogenous and Exogenous Factors to Male Alopecia Plastic and Reconstructive Surgery · 2013
    26. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    27. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    28. Establishment and Characterization of an Immortalized Human Dermal Papilla Cell Line BMB Reports · 2011
    29. Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect Journal of Dermatological Science · 2011
    30. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    31. L-Ascorbic Acid 2-Phosphate Promotes Elongation of Hair Shafts via the Secretion of Insulin-Like Growth Factor-1 from Dermal Papilla Cells Through Phosphatidylinositol 3-Kinase British journal of dermatology/British journal of dermatology, Supplement · 2009
    32. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    33. Environmental and Cosmetic Factors in Hair Loss and Damage Current problems in dermatology · 2007
    34. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    35. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    36. Finasteride Drugs · 1999
    37. Principles of Hair Cycle Control The Journal of Dermatology · 1998
    38. Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles Wound Repair and Regeneration · 1998
    39. Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells Journal of Investigative Dermatology · 1996
    40. Endothelium-Derived Relaxing Factor and Minoxidil: Active Mechanisms in Hair Growth Archives of Dermatology · 1989

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    2. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
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