Transient Stimulation of TRPMLs Enhances the Functionality of HDPCs and Facilitates Hair Growth in Mice

The study "Transient stimulation of TRPMLs enhance the functionality of hDPCs and facilitate hair growth in mice" demonstrates that transient activation of TRPMLs (a type of calcium channel involved in autophagy) promotes hair growth. The researchers found that the expression of TRPMLs increased from the telogen (resting) to anagen (growth) phase of the hair cycle. When activated by MLSA1, TRPMLs induced a calcium influx that promoted the proliferation of human Dermal Papilla Cells (hDPCs), which are essential for hair growth. This activation also enhanced the expression of hair growth promoting factors and reduced hair growth inhibiting factors. Additionally, TRPMLs counteracted oxidative stress-induced damage. The study involved male C57BL/6 mice and was conducted at Hangzhou Medical College. The findings suggest a novel function of TRPMLs in promoting hair growth.