Pungenin Promotes Hair Growth in Mouse Models of Androgenic Alopecia Through Transcriptional Regulation of the PI3K/AKT/mTOR Axis

    August 2026 in “ Molecules ”
    Wencai Zhai, Jun Yang, Lei Zhang … Gang Li
    Studysummary This study found that pungenin from Picea wilsonii Mast. showed potential in promoting hair regeneration and protecting hair follicles in a DHT-induced androgenetic alopecia mouse model.
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    Research cited in this study 25

    1. Updates on Therapeutic Approaches for Management of Androgenetic Alopecia: A Review Journal of Drugs in Dermatology · 2026
    2. Pea Sprout Extract Promotes Hair Follicle Regeneration Via Anagen Phase Prolongation And Dual Modulation Of Oxidative And Inflammatory Signaling Journal of Microbiology and Biotechnology · 2025
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    7. Corticotropin-Releasing Hormone Inhibits Autophagy by Suppressing PTEN to Promote Apoptosis in Dermal Papilla Cells Annals of Medicine · 2025
    8. Epidemiological Landscape of Androgenetic Alopecia in the US: An All of Us Cross-Sectional Study PLoS ONE · 2025
    9. Efficacy, Safety, and Tolerability of Drugs for Alopecia: A Comprehensive Review Expert Opinion on Drug Metabolism & Toxicology · 2025
    10. Research Progress on the Pathogenesis of Androgenetic Alopecia European Journal of Dermatology · 2025
    11. Network Pharmacology Reveals Curcuma Aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia Biology · 2024
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    17. Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia Journal of Dermatological Treatment · 2022
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    21. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    22. An Overview of Herbal Alternatives in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019
    23. Finasteride and Androgenic Alopecia: From Therapeutic Options to Medical Implications Journal of Dermatological Treatment · 2019
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    25. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011