Development and Validation of Androgen-Induced Hair Loss and Anagen Induction Mouse Models for Pharmacological Evaluation of Anti-Androgenic Agents

    April 2024 in “ Journal of Pharmaceutical and Pharmacological Sciences ”
    Yan Xiao-hua, Ming-Xing Cheng, Xiaoling Shen … Wenqing Yang
    Studysummary This study evaluated androgen-induced hair loss and anagen induction mouse models, finding that Minoxidil and Pyrilutamide significantly promoted hair growth by decreasing androgen receptor protein levels and enhancing the Wnt/β-Catenin signaling pathway, supporting their use in studying novel treatments for androgenetic alopecia.
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    Research cited in this study 15

    1. Development and Validation of Androgen-Induced Hair Loss and Anagen Induction Mouse Models for Pharmacological Evaluation of Anti-Androgenic Agents Journal of Pharmaceutical and Pharmacological Sciences · 2024
    2. Dihydrotestosterone Inhibits Hair Growth in Mice by Inhibiting Insulin-Like Growth Factor-I Production in Dermal Papillae Growth Hormone & IGF Research · 2024
    3. Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs Clinical, Cosmetic and Investigational Dermatology · 2023
    4. Androgens and Androgen Receptor in the Management of Skin Diseases Journal of Biosciences and Medicines · 2022
    5. Male and Female Pattern Hair Loss: Treatable and Worth Treating Cleveland Clinic Journal of Medicine · 2021
    6. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    7. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    8. Development of Finasteride Polymer Microspheres for Systemic Application in Androgenic Alopecia International Journal of Molecular Medicine · 2019
    9. Evaluating Hair Growth Promoting Effects of Candidate Substances: A Review of Research Methods Journal of Dermatological Science · 2019
    10. A Novel and Safe Small Molecule Enhances Hair Follicle Regeneration by Facilitating Metabolic Reprogramming Experimental and Molecular Medicine · 2018
    11. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    12. Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin PLOS ONE · 2015
    13. Minoxidil May Suppress Androgen Receptor-Related Functions Oncotarget · 2014
    14. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    15. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011