Defining Ovine Dermal Papilla Cell Markers and Identifying Key Signaling Pathways Regulating Its Intrinsic Properties

February 2023 in “ Frontiers in Veterinary Science ”

Shanhe Wang, Tingyan Hu, Mingliang He, Yifei Gu, Xiukai Cao, Zehu Yuan, Xiaoyang Lv, Tesfaye Getachew, Kai Quan, Wei Sun

ovine dermal papilla cells DPCs SOX18 PDGFRA hair follicle development hair regeneration Wnt/β-catenin signaling alkaline phosphatase activity FGF signaling IGF signaling hair follicle hair growth Wnt signaling fibroblast growth factor insulin-like growth factor

Studysummary This study found that ovine dermal papilla cells exhibit robust aggregation and alkaline phosphatase activity, regulated by Wnt/β-catenin signaling, providing insights for improving wool performance and hair regeneration therapies.

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