Photobiomodulation Mitigates DHT-Induced Apoptosis in Dermal Papilla Cells via Mitochondrial Rescue and Wnt/TGF-β/BMP Signaling Modulation

    July 2025 in “ Journal of Photochemistry and Photobiology B Biology ”
    Yi Ren, Xiaojing Miao, Hui Jiang … Muqing Liu
    Studysummary Photobiomodulation helps protect hair follicle cells from damage caused by DHT.
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    Research cited in this study 37

    1. Effects of Photobiomodulation on Human Hair Dermal Papilla Cells with Various Light Modes and Parameters Journal of Photochemistry and Photobiology B Biology · 2024
    2. New Plant Extracts Exert Complementary Anti-Hair Loss Properties in Human In Vitro and Ex Vivo Models Journal of Cosmetic Dermatology · 2024
    3. Restoration of Follicular β-Catenin Signaling by Mesenchymal Stem Cells Promotes Hair Growth in Mice with Androgenetic Alopecia Stem Cell Research & Therapy · 2024
    4. MitoQ Enhances CYP19A1 Expression to Stimulate WNT/β-Catenin Signaling Pathway for Promoting Hair Growth in Androgenetic Alopecia European Journal of Pharmacology · 2024
    5. Improvement of Androgenic Alopecia by Extracellular Vesicles Secreted from Hyaluronic Acid-Stimulated Induced Mesenchymal Stem Cells Stem Cell Research & Therapy · 2024
    6. The Synergistic Effect of Phototherapy and Active Substances on Hair Growth Journal of Photochemistry and Photobiology B Biology · 2024
    7. The Metabolites of Bifidobacterium Longum BB536 Alleviate DHT-Damaged Human Dermal Papilla Cells by Activating WNT/β-Catenin Signaling Food Bioscience · 2024
    8. Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2024
    9. AP Collagen Peptides (APCPs) Promote Hair Growth by Activating the GSK-3β/β-Catenin Pathway and Improve Hair Condition Experimental Dermatology · 2024
    10. Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets Molecules/Molecules online/Molecules annual · 2024
    11. Ellagic Acid Inhibits Dihydrotestosterone-Induced Ferroptosis and Promotes Hair Regeneration by Activating the Wnt/Beta-Catenin Signaling Pathway Journal of ethnopharmacology · 2024
    12. Dickkopf-Related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-Catenin Signaling Pathway in Human Dermal Papilla Cells Annals of Dermatology · 2024
    13. AP Collagen Peptides Improve Hair Growth and Quality by Promoting Human Hair Cell Proliferation and Keratin Synthesis Archives of Biological Sciences (Beograd) · 2024
    14. Progress on the Mechanism of Natural Products Alleviating Androgenetic Alopecia European Journal of Medicinal Chemistry · 2023
    15. Cyanidin-3-O-Glucoside And Its Derivative Vitisin A Alleviate Androgenetic Alopecia By Exerting Anti-Androgen Effect And Inhibiting Dermal Papilla Cell Apoptosis European Journal of Pharmacology · 2023
    16. Activation of Mitochondrial Aldehyde Dehydrogenase 2 Promotes Hair Growth in Human Hair Follicles Journal of Advanced Research · 2023
    17. Potential Application of PBM in Hair Follicle Organoid Culture for the Treatment of Androgenic Alopecia Materials Today Bio · 2023
    18. Cell-Free Fat Extract Restores Hair Loss: A Novel Therapeutic Strategy for Androgenetic Alopecia Stem Cell Research & Therapy · 2023
    19. Effects of Photobiomodulation at Various Irradiances on Normal and Dihydrotestosterone-Treated Human Hair Dermal Papilla Cells In Vitro Journal of Biophotonics · 2023
    20. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    21. The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia International Journal of Biological Sciences · 2023
    22. Photobiomodulation in 3D Tissue Engineering Journal of Biomedical Optics · 2022
    23. Development of Tea Seed Oil Nanostructured Lipid Carriers and In Vitro Studies on Their Applications in Inducing Human Hair Growth Pharmaceutics · 2022
    24. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    25. Androgens Downregulate BMP2, Impairing the Inductive Role of Dermal Papilla Cells on Hair Follicle Stem Cells Differentiation Molecular and Cellular Endocrinology · 2020
    26. The Effect of Hypoxia on the Proliferation Capacity of Dermal Papilla Cells by Regulating Lactate Dehydrogenase Journal of Cosmetic Dermatology · 2020
    27. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    28. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    29. Effect of Laser Diode Light Irradiation on Growth Capability of Human Hair Follicle Dermal Papilla Cells 2017
    30. Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways Annals of Dermatology · 2017
    31. Mechanisms and Applications of the Anti-Inflammatory Effects of Photobiomodulation AIMS biophysics · 2017
    32. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    33. Visible Red Light Enhances Physiological Anagen Entry In Vivo And Has Direct And Indirect Stimulatory Effects In Vitro Lasers in surgery and medicine · 2014
    34. Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells Biological Research · 2014
    35. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013
    36. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression Journal of Investigative Dermatology · 2007
    37. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006

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