Current and Future Pharmacotherapy for Alopecia Areata

    March 2015 in “ Expert opinion on orphan drugs ”
    Norma Elizabeth Vázquez-Herrera, Antonella Tosti
    Studysummary This review discusses recent advances in the treatment of alopecia areata, highlighting new potential therapies like JAK inhibitors and PRP, and reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 48

    1. Alopecia Universalis Successfully Treated With Adalimumab JAMA dermatology · 2014
    2. Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles International Journal of Molecular Sciences · 2014
    3. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    4. Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis Journal of Investigative Dermatology · 2014
    5. Lack of Response to Laser Comb in Spontaneous and Graft-Induced Alopecia Areata in C3H/HeJ Mice Journal of Investigative Dermatology · 2014
    6. Excimer Laser: A Module of the Alopecia Areata Common Protocol Journal of Investigative Dermatology Symposium Proceedings · 2013
    7. Current Treatment of Alopecia Areata ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2013
    8. Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children JAMA dermatology · 2013
    9. Targeted Photochemotherapy in Alopecia Areata Photodermatology Photoimmunology & Photomedicine · 2013
    10. Serum Granulysin as a Possible Key Marker of the Activity of Alopecia Areata Journal of Dermatological Science · 2013
    11. A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata British Journal of Dermatology · 2013
    12. Pulse Corticosteroid Therapy for Alopecia Areata in Children: A Retrospective Study Dermatology · 2013
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    14. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
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    16. Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series Dermatology · 2012
    17. Narrowband Ultraviolet B Phototherapy for Alopecia Areata Photodermatology Photoimmunology & Photomedicine · 2011
    18. Effects of the Lexington LaserComb on Hair Regrowth in the C3H/HeJ Mouse Model of Alopecia Areata Lasers in Medical Science · 2011
    19. The Genetics of Alopecia Areata: What's New and How Will It Help Our Patients? Dermatologic therapy · 2011
    20. Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata British journal of dermatology/British journal of dermatology, Supplement · 2011
    21. Type 1 Interferon Signature in the Scalp Lesions of Alopecia Areata British Journal of Dermatology · 2010
    22. Alopecia Areata Update Journal of the American Academy of Dermatology · 2010
    23. Medium-Dose Prednisolone Pulse Therapy in Alopecia Areata Dermato-endocrinology · 2009
    24. Alefacept for Severe Alopecia Areata: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Clinical Trial Archives of dermatology · 2009
    25. Lack of Efficacy of Topical Latanoprost and Bimatoprost Ophthalmic Solutions in Promoting Eyelash Growth in Patients with Alopecia Areata Journal of The American Academy of Dermatology · 2009
    26. Treatment of Persistent Alopecia Areata with Sulfasalazine International Journal of Dermatology · 2008
    27. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    28. The Importance of Myeloid-Derived Suppressor Cells in Regulating Autoimmune Effector Cells in Chronic Contact Eczema The Journal of Immunology · 2007
    29. Alopecia Areata: Overview and Treatment Options International Journal of Dermatology · 2007
    30. Efficacy And Safety Of A New Clobetasol Propionate 0.05% Foam In Alopecia Areata: A Randomized, Double-Blind Placebo-Controlled Trial Journal of the European Academy of Dermatology and Venereology · 2006
    31. A Comparison of the Efficacy, Relapse Rate, and Side Effects Among Three Modalities of Systemic Corticosteroid Therapy for Alopecia Areata Dermatology · 2006
    32. Alefacept for Alopecia Areata Archives of dermatology · 2005
    33. Treatment of Alopecia Areata with Anti-Interferon-Gamma Antibodies Journal of Investigative Dermatology Symposium Proceedings · 2005
    34. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    35. Recurrence of Alopecia Areata in a Patient Receiving Etanercept Injections Archives of Dermatology · 2005
    36. Placebo-Controlled Oral Pulse Prednisolone Therapy in Alopecia Areata Journal of the American Academy of Dermatology · 2005
    37. 308-Nm Excimer Laser Therapy in Alopecia Areata Journal of the American Academy of Dermatology · 2004
    38. Restoration of Hair Growth in Mice with an Alopecia Areata-Like Disease Using Topical Anthralin Experimental Dermatology · 2004
    39. Efficacy of Betamethasone Valerate Foam Formulation in Comparison with Betamethasone Dipropionate Lotion in the Treatment of Mild-to-Moderate Alopecia Areata: A Multicenter, Prospective, Randomized, Controlled, Investigator-Blinded Trial International Journal of Dermatology · 2003
    40. Clobetasol Propionate 0.05% Under Occlusion in the Treatment of Alopecia Totalis/Universalis Journal of the American Academy of Dermatology · 2003
    41. PUVA Treatment of Alopecia Areata Totalis and Universalis: A Retrospective Study Australasian journal of dermatology · 2003
    42. Cutaneous Latanoprost in the Treatment of Alopecia Areata Eye · 2003
    43. Sulfasalazine for Alopecia Areata Journal of the American Academy of Dermatology · 2002
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    45. Pulsed Administration of Corticosteroids in the Treatment of Alopecia Areata International Journal of Dermatology · 1996
    46. Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata Archives of Dermatology · 1992
    47. Increased Number of OKT6-Positive Dendritic Cells in the Hair Follicles of Patients with Alopecia Areata Dermatology · 1985
    48. Large Doses of Glucocorticoid in the Treatment of Alopecia Areata Acta dermato-venereologica · 1975

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    2. Acne Exacerbation After Tofacitinib Treatment for Alopecia Areata Dermatology Reports · 2022
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    4. Experience with Oral Tofacitinib in Severe Alopecia Areata with Different Clinical Responses Journal of Cosmetic Dermatology · 2021
    5. Topical Tofacitinib in Treatment of Alopecia Areata Einstein (São Paulo) · 2020
    6. Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata Drug design, development and therapy · 2018
    7. Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib PubMed · 2018
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