Treatment of Severe Alopecia Areata with Oral Tofacitinib: A Case Series

    June 2017 in “ Journal of the American Academy of Dermatology ”
    Image of study
    TLDR Oral tofacitinib may be an effective and tolerable treatment for some people with severe alopecia areata.
    The document reports a retrospective study on the efficacy and tolerability of oral tofacitinib, a Janus kinase inhibitor, in treating severe alopecia areata (AA). The study included 16 patients (10 females and 6 males) with a mean age of 30.2 years, who had more than 50% hair loss and were previously unresponsive to various treatments. They were treated with tofacitinib at doses of 10-15 mg/day. The results showed that 62.5% (10 out of 16) of the patients achieved a 50% improvement from baseline according to the severity of alopecia tool (SALT50). The study found that patients with persistent AA had a significantly higher frequency of being poor responders to the treatment. Mild transient side effects were reported, but overall, the treatment was well-tolerated. The conclusion suggests that oral tofacitinib could be an effective and tolerable treatment option for some patients with severe and refractory AA, but further research is needed to determine the optimal dosage, treatment duration, and to identify factors predicting poor response to tofacitinib treatment.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 8 results
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 5 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 6 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community IGE Hair Loss and Miniaturization

      in Chat  2 upvotes 2 weeks ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       7 upvotes 9 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

      community No hair, don't care! [24/F] :)

       61 upvotes 9 years ago
      A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

    Related Research

    7 / 7 results