Increased Number of OKT6-Positive Dendritic Cells in the Hair Follicles of Patients with Alopecia Areata

January 1985 in “ Dermatology ”

Akira Kohchiyama, Atsushi Hatamochi, Hiroaki Ueki

alopecia areata OKT6-positive dendritic cells hair follicles T cells pathogenesis

TLDR Higher levels of certain immune cells in hair follicles may contribute to alopecia areata.

In a study involving 18 individuals, researchers found that patients with progressive alopecia areata had a significantly higher percentage (4.9 ± 0.3%) of OKT6-positive dendritic cells in both the upper portions and bulbar area of hair follicles compared to controls (1.0 ± 0.1%) and those in the stationary stage (1.1 ± 0.1%). This suggests that these dendritic cells, in cooperation with T cells, may play a crucial role in the pathogenesis of alopecia areata.

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