Targeted Photochemotherapy in Alopecia Areata

October 2013 in “ Photodermatology Photoimmunology & Photomedicine ”

Gürol Açıkgöz, Hakan Yeşil, Ercan Çalışkan, Mustafa Tunca, Ahmet Akar

targeted photochemotherapy alopecia areata UVA phototherapy topical 8-methoxypsoralen 8-MOP patchy alopecia areata AA UVA therapy

Studysummary This study observed that combining targeted UVA phototherapy with topical 8-methoxypsoralen showed cosmetically acceptable hair regrowth in patients with patchy alopecia areata.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study assessed the efficacy and safety of targeted UVA phototherapy combined with topical 8-methoxypsoralen (8-MOP) in treating patchy alopecia areata (AA). Seven patients underwent 15 to 24 sessions of this treatment, with UVA doses ranging from 7.5 to 39.6 J/cm². The results showed an average response score of 2, indicating cosmetically acceptable hair regrowth. The study concluded that this treatment could be a viable and safe alternative for patients with patchy AA, particularly for those who are not suitable for systemic and invasive treatments.

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Research cited in this study

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research Alopecia Areata Update

244 citations , January 2010 in “Journal of the American Academy of Dermatology”

This review discusses treatment options for alopecia areata and suggests tailored treatment plans, noting the challenges posed by spontaneous remission and limited high-quality clinical trials.

research Alopecia Areata: Evidence-Based Treatments

71 citations , March 2009 in “Seminars in cutaneous medicine and surgery”

This review discusses evidence for alopecia areata treatments, highlighting their ability to stimulate hair growth but noting limited data on long-term efficacy and impact on quality of life.

research Interventions for Alopecia Areata

164 citations , April 2008 in “Cochrane library”

This review of interventions for alopecia areata found no significant treatment benefits for hair growth compared to placebo, indicating a need for larger, well-conducted studies.

research Guidelines for the Management of Alopecia Areata

182 citations , October 2003 in “British Journal of Dermatology”

These guidelines for alopecia areata management, prepared by the British Association of Dermatologists, provide evidence-based treatment recommendations and insights into the condition's epidemiology, diagnosis, and investigation.

research Efficacy of Topical Sensitizers in the Treatment of Alopecia Areata

132 citations , November 1998 in “Journal of the American Academy of Dermatology”

This review evaluates the efficacy and safety of topical sensitizers in treating alopecia areata but reports no new clinical findings.

research The Pathogenesis of Alopecia Areata

89 citations , October 1996 in “Dermatologic Clinics”

This review discusses androgenetic alopecia and alopecia areata through a systems biology lens, emphasizing the role of multi-omics data integration to explore molecular mechanisms and potential therapeutic strategies, but offers no new clinical results.

research PUVA Treatment of Alopecia Areata Partialis, Totalis, and Universalis: Audit of 10 Years' Experience at St John's Institute of Dermatology

105 citations , December 1995 in “British journal of dermatology/British journal of dermatology, Supplement”

This retrospective study concluded that PUVA treatment is generally ineffective for alopecia areata, with low effective success rates for partialis, totalis, and universalis types.

research 3 Percent Topical Minoxidil Compared With Placebo for the Treatment of Chronic Severe Alopecia Areata

26 citations , June 1988 in “PubMed”

This study found that 3 percent topical minoxidil solution was ineffective in treating severe chronic alopecia areata, as it did not produce cosmetically acceptable hair regrowth.

research Evaluation of Anthralin in the Treatment of Alopecia Areata

109 citations , November 1987 in “Archives of dermatology”

In this study, 0.5%-1.0% anthralin cream led to a cosmetic response in 25% of patients with severe alopecia areata, despite common side effects like pruritus and erythema.