Lack of Response to Laser Comb in Spontaneous and Graft-Induced Alopecia Areata in C3H/HeJ Mice

In the 2014 study involving 24 female C3H/HeJ mice, researchers evaluated the efficacy of a laser comb device for treating alopecia areata. The mice were split into two groups, with one receiving laser treatments three times a week for 12 weeks and the other serving as a control with the laser off. The results showed no significant difference in hair growth or skin histology between the treated and control mice. Consequently, the study determined that the laser comb did not promote hair regrowth in mice with extensive alopecia areata, indicating a need for further research to assess the utility of the heat shock-induced AA model for preclinical trials.