Lichen Planopilaris and Frontal Fibrosing Alopecia: Correlation of Clinical and Dermoscopic Findings with the Degree of Inflammation in Histopathological Examination

    August 2022
    Carolina Oliveira Costa Fechine
    TLDR Clinical signs don't match inflammation levels in lichen planopilaris and frontal fibrosing alopecia.
    The study investigated the correlation between clinical and dermatoscopic findings with histopathological inflammation in 103 female patients with suspected lichen planopilaris (LPP) or frontal fibrosing alopecia (AFF). The results showed a significant discrepancy between clinical symptoms and dermatoscopic signs with the degree of histopathological inflammation. While pruritus and peripilar scaling were common symptoms, histopathology revealed more intense inflammation in AFF and deeper inflammation in LPP. However, clinical and dermatoscopic variables did not correlate with histopathological inflammation, indicating that these clinical parameters did not accurately reflect the inflammatory activity of LPP or AFF, impacting diagnosis and treatment strategies.
    Discuss this study in the Community →

    Research cited in this study

    58 / 58 results

    Related Community Posts Join

    6 / 73 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 1 year ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community I think I’ve finally found the reason for my hair loss

      in Chat  98 upvotes 1 year ago
      The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

      community 9 months on Fin - no progress , should I get on Dutasteride?

      in Chat  10 upvotes 1 year ago
      The user has been using finasteride, minoxidil, and nizoral for hair loss but hasn't seen regrowth, only maintenance. They are considering switching to dutasteride, which is believed to be more effective, but are concerned about potential side effects.

    Similar Research

    5 / 1000+ results