Hair Follicles as Immune Targets: Unraveling Cellular Players, Cytokine Crosstalk, and Precision Pathways for Future Therapy of Alopecia Areata

    July 2026 in “ Expert Review of Clinical Immunology ”
    Kimia Heidari, Seyedshayan Shojaei, Arash Azari Matin, Devendra K. Agrawal
    Studysummary This review highlights that alopecia areata is characterized by three immune endotypes, and while JAK inhibitors offer temporary control, upcoming multi-omics diagnostics and immune reprogramming strategies may achieve longer-lasting remission, according to this analysis.
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    Research cited in this study 37

    1. Exosome-Based Therapies for Alopecia Areata: A Systematic Review of Clinical and Experimental Evidence International Journal of Molecular Sciences · 2025
    2. Stress-Induced Sympathetic Hyperactivation Drives Hair Follicle Necrosis to Trigger Autoimmunity Cell · 2025
    3. Alopecia Areata: From Immunopathogenesis to Emerging Therapeutic Approaches Frontiers in Immunology · 2025
    4. Sequential Immunotherapy for Alopecia Areata: Phase-Driven Immune Rebalancing Expert Review of Clinical Immunology · 2025
    5. Immune Therapies for Alopecia Areata: Evidence and New Perspectives Expert Review of Clinical Immunology · 2025
    6. From Mechanisms to Therapies: Current Advances and Breakthroughs in Alopecia Areata Immunopathology Frontiers in Immunology · 2025
    7. Evaluating Current and Emerging JAK Inhibitors for Alopecia Areata: A Narrative Review Dermatology and Therapy · 2025
    8. Integrated Single-Cell Chromatin And Transcriptomic Analyses Of Peripheral Immune Cells In Patients With Alopecia Areata Frontiers in Immunology · 2025
    9. Janus Kinase Inhibitors for Alopecia Areata: A Review of Clinical Data Frontiers in Immunology · 2025
    10. Alopecia Areata: Pathogenesis, Diagnosis, And Therapies MedComm · 2025
    11. Pathophysiology of Alopecia Areata in the Pediatric Patient Pediatric Dermatology · 2025
    12. Long-Term Safety and Efficacy of Ritlecitinib in Adults and Adolescents with Alopecia Areata and at Least 25% Scalp Hair Loss: Results from the ALLEGRO-LT Phase 3, Open-Label Study Journal of the European Academy of Dermatology and Venereology · 2025
    13. Dermal T Cell Immunity and Key Regulatory Signaling Pathways: Implications in Immune-Mediated Alopecia and Hair Regeneration Genes & Diseases · 2025
    14. Efficacy and Safety of Deuruxolitinib, an Oral Selective Janus Kinase Inhibitor, in Adults with Alopecia Areata: Results from the Phase 3 Randomized, Controlled Trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024
    15. Immune Niches for Hair Follicle Development and Homeostasis Frontiers in physiology · 2024
    16. Interleukin-15 Is a Hair Follicle Immune Privilege Guardian Journal of Autoimmunity · 2024
    17. Selective Janus Kinase 1 Inhibition Resolves Inflammation and Restores Hair Growth Offering a Viable Treatment Option for Alopecia Areata Skin health and disease · 2023
    18. Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata Frontiers in immunology · 2022
    19. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    20. Immunopathology and Immunotherapy of Inflammatory Skin Diseases Immune Network/Immune network · 2022
    21. Alopecia Areata: An Autoimmune Disease of Multiple Players ImmunoTargets and therapy · 2021
    22. A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021
    23. Immunology of Alopecia Areata Central-European Journal of Immunology/Central European Journal of Immunology · 2020
    24. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    25. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    26. Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease PloS one · 2019
    27. Pathomechanisms of Immune-Mediated Alopecia International Immunology · 2019
    28. Regulatory T-Cells in Alopecia Areata Journal of cutaneous pathology · 2019
    29. Dupilumab Improved Alopecia Areata in a Patient with Atopic Dermatitis: A Case Report Acta Dermato Venereologica · 2019
    30. Topical Tofacitinib Solution for the Treatment of Alopecia Areata Affecting Eyelashes JAAD Case Reports · 2018
    31. Immune Privilege Collapse And Alopecia Development: Is Stress A Factor Skin Appendage Disorders · 2017
    32. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    33. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    34. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    35. The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives Journal of Investigative Dermatology Symposium Proceedings · 2013
    36. Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata Clinical and Developmental Immunology · 2013
    37. Trypsin-Induced Follicular Papilla Apoptosis Results in Delayed Hair Growth and Pigmentation Developmental Dynamics · 1997