Integrated Single-Cell Chromatin And Transcriptomic Analyses Of Peripheral Immune Cells In Patients With Alopecia Areata

    July 2025 in “ Frontiers in Immunology ”
    Jesús Gay-Mimbrera, Pedro Jesús Gómez‐Arias, Pablo Álvarez-Heredia … Juan Ruano
    Studysummary This study explored peripheral blood immune dysregulation in alopecia areata through single-cell analyses, identifying systemic changes linked to disease severity and key signaling roles for monocytes, NK cells, and memory T cells, suggesting potential therapeutic targets.
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    Research cited in this study 17

    1. European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    2. A Case of Atopic Dermatitis with Self-Healing Acute Diffuse and Total Alopecia During Nemolizumab Treatment The Journal of Dermatology · 2023
    3. Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions Frontiers in immunology · 2023
    4. Markers of Venous Thromboembolism Risk in Patients with Alopecia Areata: Is There Anything to Worry About? Dermatology and therapy · 2023
    5. A Novel Predictive Model for the Recurrence of Pediatric Alopecia Areata by Bioinformatics Analysis and a Single-Center Prospective Study Frontiers in Medicine · 2023
    6. Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms Precision clinical medicine · 2023
    7. Differential Impact of Environmental Factors on Systemic and Localized Autoimmunity Frontiers in immunology · 2023
    8. Ex Vivo Treatment with Allogenic Mesenchymal Stem Cells on Peripheral Blood Mononuclear Cells of Patients with Severe Alopecia Areata International Journal of Molecular Sciences · 2022
    9. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    10. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    11. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    12. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    13. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    14. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    15. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    16. The Role of Sebaceous Gland Activity and Scalp Microfloral Metabolism in the Etiology of Seborrheic Dermatitis and Dandruff Journal of Investigative Dermatology Symposium Proceedings · 2005
    17. Apoptosis Resistance in Peripheral Blood Lymphocytes of Alopecia Areata Patients Journal of Autoimmunity · 2004