Advances in Single-Cell Transcriptomics in Animal Research

    Yunan Yan, Senlin Zhu, Minghui Jia, Xinyi Chen, Wenlingli Qi, Fengfei Gu, Teresa G. Valencak, Jianxin Liu, Hui‐Zeng Sun
    Single-cell transcriptomics is a promising biotechnology that has been increasingly applied in animal research to study gene expression at the single-cell level across various tissues and organs. This paper reviews the development and applications of this technology, highlighting its role in identifying cell types, inferring cellular trajectories, and understanding cell interactions. It emphasizes recent advancements in animal nutrition, health, reproductive performance, genetics, and disease models in livestock. The paper also discusses practical considerations such as sample size and cell clustering, as well as the current limitations and future prospects of single-cell transcriptomics in enhancing agricultural productivity and animal health.
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