Modeling Animal Genomics in Mice: An Authentic Approach for the Functional Interrogation of Evolutionarily and Agriculturally Critical Variants

January 2024 in “ Animal Research and One Health ”

Peter Kalds, Shiwei Zhou, Yulin Chen, Xiaolong Wang

CRISPR/Cas9 β-catenin hair follicle density genomic sequencing gene-editing multi-omic analyses CRISPR gene editing

Studysummary This commentary highlights the potential of using transgenic and genome-edited mouse models to validate findings from livestock genomic and multi-omic analyses, aiding in the understanding of economically significant animal traits.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Epigenetic Mechanism of Gtl2-miRNAs Causes the Primitive Sheep Characteristics Found in Purebred Merino Sheep

October 2023 in “Cell & bioscience”

This study identified a primitive coarse wool characteristic in Merino sheep that enhances environmental adaptability and fine wool yield without reducing quality, suggesting that epigenetic mechanisms, particularly involving the imprinted Gtl2-miRNAs locus, regulate this advantageous trait.

research Skin-Specific Transgenic Overexpression of Ovine β-Catenin in Mice

2 citations , January 2023 in “Frontiers in Genetics”

This study found that overexpression of ovine β-catenin in transgenic mice increased hair follicle density by promoting the transition from catagen to anagen.