Phenotyping Mice With Skin, Hair, Or Nail Abnormalities: A Systematic Approach And Methodologies From Simple To Complex

    May 2023 in “ Veterinary Pathology ”
    John P. Sundberg, Robert H. Rice
    Studysummary This article outlines methods to study the skin and its molecular traits, focusing on interpretation and techniques applicable to mouse models, including diverse assays and approaches like electron microscopy and large-scale lipid analyses.
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    Research cited in this study 25

    1. Optimal Processing for Proteomic Genotyping of Single Human Hairs Forensic Science International Genetics · 2020
    2. 2-Deoxy D-Glucose Treatment Does Not Elicit a Hair Growth Response in Alopecia Areata Experimental Dermatology · 2019
    3. Human Stratum Corneum Proteomics Reveals Cross-Linking of a Broad Spectrum of Proteins in Cornified Envelopes Experimental Dermatology · 2019
    4. Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia PloS one · 2018
    5. A Keratin Scaffold Regulates Epidermal Barrier Formation, Mitochondrial Lipid Composition, And Activity The Journal of Cell Biology · 2015
    6. Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function Cell Death and Disease · 2015
    7. What Color Is the Skin of a Mouse? Veterinary Pathology · 2011
    8. Comparisons of Mouse Models for Hair Follicle Reconstitution Experimental Dermatology · 2011
    9. Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans Veterinary pathology · 2010
    10. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    11. Mutations in Sterol O-Acyltransferase 1 (SOAT1) Result in Hair Interior Defects in AKR/J Mice Journal of Investigative Dermatology · 2010
    12. Distinguishing Mouse Strains by Proteomic Analysis of Pelage Hair Journal of Investigative Dermatology · 2009
    13. FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    14. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002
    15. Lanceolate Hair-J (LahJ): A Mouse Model for Human Hair Disorders Experimental dermatology · 2000
    16. Cross-Linked Features of Mouse Pelage Hair Resistant to Detergent Extraction ˜The œanatomical record · 1999
    17. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    18. Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding Locus ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1997
    19. Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression Veterinary Pathology · 1997
    20. Lanceolate Hair (Lah): A Recessive Mouse Mutation with Alopecia and Abnormal Hair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1996
    21. Ultrastructural Visualization of Cross-Linked Protein Features in Epidermal Appendages Journal of Cell Science · 1994
    22. Alopecia Areata in Aging C3H/HeJ Mice Journal of Investigative Dermatology · 1994
    23. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools Medical Entomology and Zoology · 1994
    24. Quantitative Models for the Study of Hair Growth In Vivo Annals of the New York Academy of Sciences · 1991
    25. Critical Stages of Hair Development and Pigmentation in the Mouse Physiological zoology · 1951

    Related research 5

    1. Cholesterol Homeostasis: Links to Hair Follicle Biology and Hair Disorders Experimental Dermatology · 2019
    2. Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: An Update Journal of Dermatological Science · 2012
    3. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    4. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    5. Trichostasis Spinulosa International Journal of Dermatology · 1979