Optimal Processing for Proteomic Genotyping of Single Human Hairs

    May 2020 in “ Forensic Science International Genetics ”
    Zachary C. Goecker, Michelle Salemi, Noreen Karim … Glendon J. Parker
    Studysummary This study found that optimizing proteomic genotyping conditions from single human hair samples significantly improves the detection of genetically variant peptides, enhancing human identification with high precision across different biogeographic backgrounds.
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    Research cited in this study 13

    1. Assessing Protein Sequencing in Human Single Hair Shafts of Decreasing Lengths Forensic Science International Genetics · 2019
    2. Variation in Human Hair Ultrastructure Among Three Biogeographic Populations Journal of structural biology · 2018
    3. Protein Extraction from Human Anagen Head Hairs 1 Millimeter or Less in Total Length Biotechniques/BioTechniques · 2018
    4. Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, And Cuticle Analysis PeerJ · 2014
    5. Structure and Mechanical Properties of Human Trichocyte Keratin Intermediate Filament Protein Biomacromolecules · 2012
    6. Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments Analytical biochemistry · 2011
    7. Proteomic Analysis of Hair Shaft and Nail Plate PubMed · 2011
    8. Characterization of Low Abundance Wool Proteins Through Novel Differential Extraction Techniques Electrophoresis · 2010
    9. Hair Cuticle Differences Between Asian And Caucasian Females International Journal of Dermatology · 2006
    10. Proteome Analysis of Human Hair Shaft Molecular & Cellular Proteomics · 2006
    11. Human Hair Keratin-Associated Proteins International review of cytology · 2006
    12. A Rapid Extraction Procedure of Human Hair Proteins and Identification of Phosphorylated Species Biological and Pharmaceutical Bulletin · 2002
    13. Pathologic Dynamics of Human Hair Loss Archives of Dermatology · 1961