Proteomic Analysis of Single Hairs

    December 2024 in “ Methods in molecular biology ”
    Nicole M McLoughlin, Rebecca Tidy, Rebecca J Tidy, Zachary C. Goecker, Robert H. Rice, Joel P. A. Gummer, Ashley M. Spicer, Glendon Parker
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    TLDR Hair proteins are complex and provide valuable genetic and biological information.
    The study "Proteomic Analysis of Single Hairs" explores the complex proteome of the hair shaft, which includes structural proteins like keratins and proteins involved in cellular processes before cornification. The hair shaft's proteome provides valuable biological, genetic, and phylogenetic information due to its robust protein matrix. The research highlights the challenges in processing hair samples due to their chemical resilience, requiring specific chemistries to access the proteome without introducing modifications. This analysis is significant for various fields, including genetics, developmental biology, toxicology, forensics, cosmetics, and ecology, offering insights into the biological and chemical properties of hair.
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