Proteomic Analysis of Single Hairs

December 2024 in “ Methods in molecular biology ”

Nicole M McLoughlin, Rebecca Tidy, Rebecca J Tidy, Zachary C. Goecker, Robert H. Rice, Joel P. A. Gummer, Ashley M. Spicer, Glendon Parker

proteomic analysis hair shaft structural proteins amino acid sequence genetics toxicology forensics cosmetics ecology

TLDR Hair proteins are complex and provide valuable genetic and biological information.

The study "Proteomic Analysis of Single Hairs" explores the complex proteome of the hair shaft, which includes structural proteins like keratins and proteins involved in cellular processes before cornification. The hair shaft's proteome provides valuable biological, genetic, and phylogenetic information due to its robust protein matrix. The research highlights the challenges in processing hair samples due to their chemical resilience, requiring specific chemistries to access the proteome without introducing modifications. This analysis is significant for various fields, including genetics, developmental biology, toxicology, forensics, cosmetics, and ecology, offering insights into the biological and chemical properties of hair.

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Research cited in this study

11 / 11 results

research Ancient Lineages of the Keratin-Associated Protein (KRTAP) Genes and Their Co-Option in the Evolution of the Hair Follicle

2 citations , March 2023 in “BMC ecology and evolution”

Some hair protein genes evolved early and were adapted for use in hair follicles.

research Human Pollution Exposure Correlates With Accelerated Ultrastructural Degradation of Hair Fibers

23 citations , August 2019 in “Proceedings of the National Academy of Sciences of the United States of America”

Pollution exposure speeds up hair damage.

research Genetic Hair Disorders: A Review

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The conclusion is that genetic testing is important for diagnosing and treating various genetic hair disorders.

research Studies on the Proteome of Human Hair: Identification of Histones and Deamidated Keratins

54 citations , January 2018 in “Scientific reports”

Human hair contains diverse proteins, including keratins and histones, which could help assess hair health and aging.

research Emerging Diagnostic and Therapeutic Potentials of Human Hair Proteomics

14 citations , September 2017 in “Proteomics. Clinical applications”

Hair protein analysis could improve medical testing and understanding of hair characteristics.

research The Structure of People's Hair

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Hair's molecular structure is mostly consistent, but genetic differences affect lipid types, which could help diagnose diseases.

research Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, And Cuticle Analysis

68 citations , August 2014 in “PeerJ”

Human hair proteins vary by individual, body site, and ethnicity, useful for forensics.

research Proteomic Analysis of Hair Shaft and Nail Plate

29 citations , August 2011 in “PubMed”

Hair and nail proteins, mainly keratins, are crucial for structure and can indicate health issues.

research Proteome Analysis of Human Hair Shaft

122 citations , January 2006 in “Molecular & Cellular Proteomics”

Human hair contains many proteins, with some being highly abundant and modified.

research Human Hair: A Unique Physicochemical Composite

203 citations , June 2003 in “Journal of the American Academy of Dermatology”

Human hair, despite its different types, shares common traits that affect its structure and response to treatments.

research A Rapid Extraction Procedure of Human Hair Proteins and Identification of Phosphorylated Species

226 citations , January 2002 in “Biological and Pharmaceutical Bulletin”

A new method quickly extracts and identifies proteins from hair and other keratin sources.

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research Bald Thigh Syndrome in Sighthounds: Revisiting the Cause of a Well-Known Disease

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Bald thigh syndrome in sighthounds is caused by structural defects in hair shafts due to downregulated genes and proteins.

research Peer Review of Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, and Cuticle Analysis

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The research found that people's hair proteins vary, especially by ethnicity and body part, which could help identify individuals in forensic science.

Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, and Cuticle Analysis

Proteomic Analysis of Single Hairs

Research cited in this study

research Ancient Lineages of the Keratin-Associated Protein (KRTAP) Genes and Their Co-Option in the Evolution of the Hair Follicle

research Human Pollution Exposure Correlates With Accelerated Ultrastructural Degradation of Hair Fibers

research Genetic Hair Disorders: A Review

research Studies on the Proteome of Human Hair: Identification of Histones and Deamidated Keratins

research Emerging Diagnostic and Therapeutic Potentials of Human Hair Proteomics

research The Structure of People's Hair

research Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, And Cuticle Analysis

research Proteomic Analysis of Hair Shaft and Nail Plate

research Proteome Analysis of Human Hair Shaft

research Human Hair: A Unique Physicochemical Composite

research A Rapid Extraction Procedure of Human Hair Proteins and Identification of Phosphorylated Species

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