Wounds And The Microbiota: The Healing Interplay Between Host And Microbial Communities

November 2025 in “ International Journal of Molecular Sciences ”

Raghad Al-Taweel, Ayat S. Hammad, Ali Tajammul, Sérgio Crovella, Maha Al‐Asmakh

skin microbiota hemostasis inflammation proliferation remodeling Staphylococcus epidermidis Lactobacillus plantarum antimicrobial peptides cytokine production Staphylococcus aureus Pseudomonas aeruginosa Enterococcus faecalis biofilm formation proteolytic activity microbiome-targeted therapies

TLDR Balancing good and harmful microbes is key to healing chronic wounds.

The document explores the complex interplay between the skin microbiota and wound healing, emphasizing the importance of maintaining a balanced microbial community for effective recovery. Beneficial microbes like Staphylococcus epidermidis aid in tissue repair and immune modulation, while pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa hinder healing through biofilm formation and chronic inflammation. The review highlights the potential for microbiome-targeted therapies, including probiotics and bacteriophage treatments, to enhance wound management by restoring microbial equilibrium. Advances in sequencing and systems biology have improved understanding of microbial roles in wound healing, paving the way for precision medicine approaches.

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