Dynamic Remodeling of Skin Microbiota During Healthy Homeostatic and Wound Repair Conditions

The review explores the dynamic interactions between skin microbiota and the host during healthy skin conditions and wound repair, emphasizing the crucial role of commensal microorganisms in maintaining skin homeostasis, regulating immune responses, and facilitating wound healing. It highlights how skin injury disrupts microbial balance, leading to changes in the local microenvironment, but commensals play beneficial roles during the inflammatory, proliferative, and remodeling phases of wound healing. The document discusses the potential of microbiota-based therapies for wound management and the need for further research to harness the positive functions of skin microbes in promoting tissue repair and restoring microbial homeostasis. Additionally, it explores microbiota-based therapeutic strategies, including live microorganisms and microbiota-derived bioactive molecules, to support wound healing, while acknowledging the challenges and risks associated with using microbes in wound treatment, particularly in immunocompromised individuals.