Microbial Allies in Skin Trauma Recovery: From Immune Modulation to Engineered Probiotic Therapeutics

October 2025 in “ Burns & Trauma ”

Aline Yen Ling Wang, Ana Elena Aviña, Yen‐Yu Liu, Huang‐Kai Kao

skin microbiome wound healing commensal bacteria probiotic bacteria immunomodulation tissue repair engineered probiotics Lactobacillus reuteri Lactococcus cremoris diabetic foot ulcers probiotic therapies chronic wounds probiotics good bacteria

TLDR Engineered probiotics can help heal wounds faster, especially in diabetic foot ulcers.

The review highlights the role of the skin microbiome in wound healing, focusing on how commensal and probiotic bacteria contribute to immunomodulation and tissue repair. It discusses the integration of immunological concepts with material science and synthetic biology to develop engineered probiotics for improved wound treatments. Notably, genetically engineered strains like <i>Lactobacillus reuteri</i> and <i>Lactococcus cremoris</i> have shown promise in accelerating wound healing in animal models and clinical trials, particularly for diabetic foot ulcers. These advancements in probiotic therapies, including enhanced delivery systems, offer potential alternative strategies for treating chronic wounds and related complications.

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