Microbial Allies in Skin Trauma Recovery: From Immune Modulation to Engineered Probiotic Therapeutics

    October 2025 in “ Burns & Trauma ”
    Aline Yen Ling Wang, Ana Elena Aviña, Yen‐Yu Liu, Huang‐Kai Kao
    Studysummary This review highlights recent advancements in engineered probiotics for wound healing, reporting that genetically engineered strains of <i>Lactobacillus reuteri</i> and <i>Lactococcus cremoris</i> have shown promise in promoting faster wound healing in pre-clinical and clinical settings, particularly for diabetic foot ulcers.
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    Research cited in this study 7

    1. First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide Current Issues in Molecular Biology · 2025
    2. Wound Microbiota and Its Impact on Wound Healing International journal of molecular sciences · 2023
    3. Recent Advances in Single-Cell Engineered Live Biotherapeutic Products Research for Skin Repair and Disease Treatment npj biofilms and microbiomes · 2023
    4. The Role of the Skin Microbiome in Wound Healing Burns and trauma · 2023
    5. Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds With Endoplasmic Reticulum Stress-Relieving Properties For Promoted Scarless Wound Healing ACS Applied Materials & Interfaces · 2023
    6. Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism Science Advances · 2023
    7. Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation International Journal of Molecular Sciences · 2021