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research Dynamic remodeling of skin microbiota during healthy homeostatic and wound repair conditions

February 2026 in “Frontiers in Microbiology”

This review examines current understanding of how skin microbiota interact with and influence wound healing, highlighting the roles of commensal microorganisms in inflammation resolution, tissue regeneration, and barrier restoration, and discusses potential microbiota-based therapies for improving wound management.

research Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection

February 2024 in “International journal of molecular sciences”

This study reviews current evidence on the role of ILC3s in the skin, highlighting their potential involvement in responding to microbiome changes such as those associated with acne and suggesting gaps in understanding their mechanisms.

research Eavesdropping on the conversation between immune cells and the skin epithelium

10 citations , January 2019 in “International Immunology”

This review discusses the interactions between immune cells and the skin epithelium and their impact on maintaining barrier function, emphasizing the potential to enhance epithelial barrier function in inflammatory diseases.

research Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities

2 citations , November 2025 in “International Journal of Molecular Sciences”

This review highlights that the skin microbiota plays a crucial role in wound healing, with beneficial microorganisms aiding tissue repair and opportunistic pathogens hindering it, potentially guiding future microbiome-targeted therapies.

research Acne: Transient Arrest in the Homeostatic Host–Microbiota Dialog?

22 citations , September 2019 in “Trends in Immunology”

This paper proposes that acne vulgaris is a transient inflammatory response during adolescence due to changes in facial skin's microbiota and sebum environment rather than a stable skin condition.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community What if DHT is not the vilan.

13 upvotes 5 years ago

Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

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SMP Specialist
Noelle Skin
Nice, France

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Noelle Skin